About this book
Calcium ions represent Mother Nature’s ‘ion-of-choice’ for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies.
The editors, Norbert Weiss and Alexandra Koschak, have been extraordinary successful in bringing together so many of the major researchers in this rapidly expanding field. To have all this information in a single volume is a fantastic resource for both those workers actively involved in this exciting field and for those wishing to find out more about particular diseases.
Sir Michael Berridge
Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels.
Content
Preface
Sir Michael Berridge
Sir Michael Berridge
Part 1. Pathologies of Voltage-gated Calcium Channels
Cav2.1 Channels and Migraine
Daniela Pietrobon
Ataxia and CACNA1A: Episodic or Progressive?
Stephanie Schorge, Kinya Ishikawa
Role of L-Type Ca2+ Channels in Sensory Cells
Alexandra Koschak, Alexandra Pinggera, Klaus Schicker, Jörg Striessnig
T-Type Calcium Channels and Epilepsy
Stuart M. Cain, Michael E. Hildebrand, Terrance P. Snutch
Stuart M. Cain, Michael E. Hildebrand, Terrance P. Snutch
The Involvement of Calcium Channel α2δ Subunits in Diseases and as a Therapeutic Target
Annette C. Dolphin
Annette C. Dolphin
T-Type Calcium Channels in Pain Neuronal Circuits
Amaury Francois, Anne Pizzoccaro, Sophie Laffray, Emmanuel Bourinet
Amaury Francois, Anne Pizzoccaro, Sophie Laffray, Emmanuel Bourinet
Cav1.1 Channel and Hypokalemic Periodic Paralysis
Emma Matthews, Michael G. Hanna
Cav1.1 in Malignant Hyperthermia
Viktor Yarotskyy, Robert T. Dirksen
Ryanodine Receptor 1 and Associated Pathologies
Julien Fauré, Joël Lunardi, Nicole Monnier, Isabelle Marty
Emma Matthews, Michael G. Hanna
Cav1.1 in Malignant Hyperthermia
Viktor Yarotskyy, Robert T. Dirksen
Ryanodine Receptor 1 and Associated Pathologies
Julien Fauré, Joël Lunardi, Nicole Monnier, Isabelle Marty
The Lambert-Eaton Myasthenic Syndrome
Paul W. Wirtz, Maarten J. Titulaer, Jan J. G. M. Verschuuren
Paul W. Wirtz, Maarten J. Titulaer, Jan J. G. M. Verschuuren
Alternative Exon Effect on Phenotype of Cav1.2 Channelopathy: Implications in Timothy Syndrome
Hua Huang, Juejin Wang, Tuck Wah Soong
Brugada Syndrome and Voltage-Gated Calcium Channels
Brett Simms
Cav1.3 Channels and Sino-Atrial Node Dysfunction
Pietro Mesirca, Matteo E. Mangoni
Auxiliary β-Subunits of L-Type Ca2+ Channels in Heart Failure
Jan Matthes, Stefan Herzig
Epigenetic, Genetic, and Acquired Regulation of Cav3 T-Type Calcium Channel Expression and Function in Tumor Growth and Progression
Maria Beatrice Morelli, Sonia Liberati, Consuelo Amantini, Matteo Santoni, Massimo Nabissi, Valerio Farfariello et al.
Pharmacology of Voltage-Gated Calcium Channels in Clinic
Lubica Lacinová, Lucia Lichvárová
Hua Huang, Juejin Wang, Tuck Wah Soong
Brugada Syndrome and Voltage-Gated Calcium Channels
Brett Simms
Cav1.3 Channels and Sino-Atrial Node Dysfunction
Pietro Mesirca, Matteo E. Mangoni
Auxiliary β-Subunits of L-Type Ca2+ Channels in Heart Failure
Jan Matthes, Stefan Herzig
Epigenetic, Genetic, and Acquired Regulation of Cav3 T-Type Calcium Channel Expression and Function in Tumor Growth and Progression
Maria Beatrice Morelli, Sonia Liberati, Consuelo Amantini, Matteo Santoni, Massimo Nabissi, Valerio Farfariello et al.
Pharmacology of Voltage-Gated Calcium Channels in Clinic
Lubica Lacinová, Lucia Lichvárová
Part 2. Pathologies of Transient Receptor Potential Channels
TRPM1 and Congenital Stationary Night Blindness
Shoichi Irie, Takahisa Furukawa
Alterations in TRPM2 and TRPM7 Functions in the Immune System Could Confer Susceptibility to Neurodegeneration
Meredith C. Hermosura
TRPML Channels and Mucolipidosis Type IV
Christian Grimm, Math P. Cuajungco
Transient Receptor Potential Channels and Pain
Alexandre Denadai-Souza, Nicolas Cenac
Hereditary Channelopathies Caused by TRPV4 Mutations
Jeremy M. Sullivan, Thomas E. Lloyd, Charlotte J. Sumner
TRPC Channels in Cardiac Hypertrophy
Nadine Kirschmer, Kristina Lorenz, Petra Eder-Negrin
Role of TRPC and Orai Channels in Vascular Remodeling
Michael Poteser, Sarah Krenn, Klaus Groschner
TRPP2 in Polycystic Kidney Disease
Andrew Streets, Albert Ong
TRPM6 and Hypomagnesaemia/Hypocalcaemia
Daniel Landau, Hanna Shalev
TRP Channels in Prostate Cancer
George Shapovalov, Roman Skryma, Natalia Prevarskaya
Pharmacology of TRPV Channels
Ulrich Wissenbach
Michael Poteser, Sarah Krenn, Klaus Groschner
TRPP2 in Polycystic Kidney Disease
Andrew Streets, Albert Ong
TRPM6 and Hypomagnesaemia/Hypocalcaemia
Daniel Landau, Hanna Shalev
TRP Channels in Prostate Cancer
George Shapovalov, Roman Skryma, Natalia Prevarskaya
Pharmacology of TRPV Channels
Ulrich Wissenbach
Part 3. Pathologies of Ligand-Gated Calcium Channels
IP3 Receptors in Neurodegenerative Disorders: Spinocerebellar Ataxias and Huntington’s and Alzheimer’s Diseases
Masayoshi Tada, Masatoyo Nishizawa, Osamu Onodera
RyR2 in Cardiac Disorders
Ineke Nederend, Christian van der Werf, Arthur A. M. Wilde
P2X Receptors and Pain
François Rassendren, Lauriane Ulmann
François Rassendren, Lauriane Ulmann
P2X7 in Bipolar and Depressive Disorders
Melissa L. Barron, Eryn L. Werry, Iain S. McGregor, Michael Kassiou
Melissa L. Barron, Eryn L. Werry, Iain S. McGregor, Michael Kassiou
Targeting NMDA Receptors in Epilepsy
Mehdi Ghasemi, Ahmad Reza Dehpour
Nicotinic AChR in Congenital Myasthenic Syndromes
Francesca Grassi, Sergio Fucile
CatSper in Male Infertility
Takuya Nishigaki, Ana Laura González‐Cota, Gerardo José Orta Salazar
Mehdi Ghasemi, Ahmad Reza Dehpour
Nicotinic AChR in Congenital Myasthenic Syndromes
Francesca Grassi, Sergio Fucile
CatSper in Male Infertility
Takuya Nishigaki, Ana Laura González‐Cota, Gerardo José Orta Salazar
