The WEISS Lab

Pathophysiology of Ion Channels

Five Year Publications


2023


Extended spectrum of Cav1.3 channelopathies


E. R. Mustafá, N. Weiss

Pflügers Archiv: European Journal of Physiology, 2023


Electrophysiological characterization of a Cav3.2 calcium channel missense variant associated with epilepsy and hearing loss


Robin N. Stringer, Leos Cmarko, Gerald W. Zamponi, Michel De Waard, Norbert Weiss

Molecular Brain, 2023


2022


Cavβ surface charged residues contribute to the regulation of neuronal calcium channels


A. Tran-van-Minh, M. De Waard, N. Weiss

Molecular brain, 2022


Electrophysiological and computational analysis of Cav3.2 channel variants associated with familial trigeminal neuralgia


E. R. Mustafá, Eder Gambeta, Robin N. Stringer, I. A. Souza, G. Zamponi, N. Weiss

Molecular Brain, 2022


Secretory carrier-associated membrane protein 2 (SCAMP2) regulates cell surface expression of T-type calcium channels


Leos Cmarko, Robin N Stringer, Bohumila Jurkovicova-Tarabova, T. Vacík, Ľ. Lacinová, N. Weiss

Molecular brain, 2022


T‐type channels: A new route for calcium entry into platelets


N. Weiss

Journal of Thrombosis and Haemostasis , 2022


The omega of TRPM7 channels in trigeminal neuralgia


N. Weiss, G. Zamponi

Pflügers Archiv: European Journal of Physiology, 2022


Trafficking of neuronal calcium channels


N. Weiss, R. Khanna

G. Zamponi, N. Weiss, Voltage-gated calcium channels, Springer, 2022


Screening an In-House Isoquinoline Alkaloids Library for New Blockers of Voltage-Gated Na+ Channels Using Voltage Sensor Fluorescent Probes: Hits and Biases


Q. Coquerel, Claire Legendre, J. Frangieh, S. D. Waard, J. Montnach, Leos Cmarko, J. Khoury, Charifat Said Hassane, D. Bréard, B. Siegler, Z. Fajloun, H. de Pomyers, K. Mabrouk, N. Weiss, D. Henrion, P. Richomme, C. Mattei, M. Waard, A. Le Ray, C. Legros

Molecules, 2022


2021


Trigeminal neuropathic pain is alleviated by inhibition of Cav3.3 T-type calcium channels in mice


M. Montera, A. Goins, Leos Cmarko, N. Weiss, Karin N Westlund High, Sascha R. A. Alles

Channels, 2021


Opioid Receptor Regulation of Neuronal Voltage-Gated Calcium Channels


N. Weiss, G. Zamponi

Cellular and Molecular Neurobiology, 2021


De novo SCN8A and inherited rare CACNA1H variants associated with severe developmental and epileptic encephalopathy


Robin N Stringer, Bohumila Jurkovicova-Tarabova, I. A. Souza, J. Ibrahim, T. Vacík, W. Fathalla, J. Hertecant, G. Zamponi, Ľ. Lacinová, N. Weiss

Molecular brain, 2021


2020


A rare CACNA1H variant associated with amyotrophic lateral sclerosis causes complete loss of Cav3.2 T-type channel activity


Robin N Stringer, Bohumila Jurkovicova-Tarabova, Sun Huang, O. Haji-Ghassemi, Romane Idoux, A. Liashenko, I. A. Souza, Y. Rzhepetskyy, Ľ. Lacinová, F. van Petegem, G. Zamponi, R. Pamphlett, N. Weiss

Molecular Brain, 2020


Functional identification of potential non-canonical N-glycosylation sites within Cav3.2 T-type calcium channels


Vendula Ficelova, I. A. Souza, Leos Cmarko, M. Gandini, Robin N Stringer, G. Zamponi, N. Weiss

Molecular brain, 2020


2019


A potential role for T-type calcium channels in homocysteinemia-induced peripheral neuropathy.


Aisylu S Gaifullina, J. Lazniewska, E. Gerasimova, Gulshat Burkhanova, Y. Rzhepetskyy, A. Tomin, P. Rivas-Ramírez, Junting Huang, Leos Cmarko, G. Zamponi, G. Sitdikova, N. Weiss

Pain, 2019


Identification of a molecular gating determinant within the carboxy terminal region of Cav3.3 T-type channels


Bohumila Jurkovicova-Tarabova, Leos Cmarko, R. Rehak, G. Zamponi, Ľ. Lacinová, N. Weiss

Molecular Brain, 2019


Compound heterozygous CACNA1H mutations associated with severe congenital amyotrophy


M. Carter, H. McMillan, A. Tomin, N. Weiss

Channels, 2019


T-type calcium channels: From molecule to therapeutic opportunities.


N. Weiss, G. Zamponi

The international journal of biochemistry & cell biology, 2019


Genetic T-type calcium channelopathies


N. Weiss, G. Zamponi

Journal of Medical Genetics, 2019


T-Type Channel Druggability at a Crossroads.


N. Weiss, G. Zamponi

ACS chemical neuroscience, 2019


2017


Glycosylation of voltage-gated calcium channels in health and disease.


J. Lazniewska, N. Weiss

Biochimica et biophysica acta. Biomembranes, 2017


The Cacna1h mutation in the GAERS model of absence epilepsy enhances T-type Ca2+ currents by altering calnexin-dependent trafficking of Cav3.2 channels


J. Proft, Y. Rzhepetskyy, J. Lazniewska, F. Zhang, S. Cain, T. Snutch, G. Zamponi, N. Weiss

Scientific Reports, 2017


Trafficking of neuronal calcium channels


N. Weiss, G. Zamponi

Neuronal signaling, 2017


Surfen is a broad-spectrum calcium channel inhibitor with analgesic properties in mouse models of acute and chronic inflammatory pain


P. Rivas-Ramírez, V. M. Gadotti, G. Zamponi, N. Weiss

Pflügers Archiv - European Journal of Physiology, 2017



2016


Glycosylation of α2δ1 subunit: a sweet talk with Cav1.2 channels.


J. Lazniewska, N. Weiss

General physiology and biophysics, 2016


Cooperative roles of glucose and asparagine-linked glycosylation in T-type calcium channel expression


J. Lazniewska, Y. Rzhepetskyy, F. Zhang, G. Zamponi, N. Weiss

Pflügers Archiv - European Journal of Physiology, 2016


Modulation of Cav3.2 T-type calcium channel permeability by asparagine-linked glycosylation


Katarína Ondáčová, M. Karmažínová, J. Lazniewska, N. Weiss, Ľ. Lacinová

Channels, 2016


It takes two T to shape immunity: emerging role for T-type calcium channels in immune cells.


Ľ. Lacinová, N. Weiss

General physiology and biophysics, 2016


T-type channels: release a brake, engage a gear


N. Weiss, Ľ. Lacinová

Channels, 2016


A Cav3.2/Stac1 molecular complex controls T-type channel expression at the plasma membrane


Y. Rzhepetskyy, J. Lazniewska, J. Proft, M. Campiglio, B. Flucher, N. Weiss

Channels, 2016

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